Journal of Emergencies, Trauma, and Shock

ORIGINAL ARTICLE
Year
: 2017  |  Volume : 10  |  Issue : 3  |  Page : 116--120

Effectiveness and safety of polygeline in patients with hypovolemia due to trauma


Ajai Singh1, Sabir Ali1, Rohita Shetty2 
1 Department of Orthopedic Surgery, King George's Medical University, Lucknow, Uttar Pradesh, India
2 Acute Care Division, Abbott Healthcare Pvt Ltd, Mumbai, Maharashtra, India

Correspondence Address:
Ajai Singh
Department of Orthopedic Surgery, King George's Medical University, Lucknow, Uttar Pradesh
India

Background: This retrospective study examined the effectiveness and safety of polygeline in adult patients with hypovolemia due to traumatic injury. Materials and Methods: Polygeline was administered after evaluating the amount of blood loss and estimating hematological and biochemical parameters. Changes in vital signs, serum electrolytes, arterial pH, and serum lactate were evaluated. The safety was evaluated by recording the adverse events if any. Results: Sixty patients with the mean age 37.5 ± 11.26 years were included in the study. All patients had blood loss <20%. The mean total polygeline administered was 1025.0 ± 464.18 ml. Blood transfusion was required in 3.33% of patients. Diastolic, systolic, and mean arterial blood pressure and pulse rate significantly increased after 1 h of polygeline administration (P < 0.0001). There was a trend toward increase in urine output (P = 0.0715) after 1 h. The improvement in vital parameters was consistent at 6, 14, and 18 h after administration of polygeline. Arterial pH significantly increased from 7.2 ± 0.12 to 7.3 ± 0.11 after 1 h of administration (P < 0.0001) and was consistent till 24 h (P = 0.035). Blood lactate decreased after 1 h (P < 0.0001). Changes in laboratory parameters were not clinically significant. After mean duration hospital stay of 10.5 ± 4.63 days all patients were discharged without any clinically significant abnormality or adverse event. Conclusion: Polygeline improved hemodynamic stability in patients with hypovolemia due to traumatic injury. The improvement was seen within 1 h (golden hour) of polygeline administration and maintained consistently. Polygeline can be safely administered to patients with traumatic injury to improve hemodynamic parameters and achieve stability.


How to cite this article:
Singh A, Ali S, Shetty R. Effectiveness and safety of polygeline in patients with hypovolemia due to trauma.J Emerg Trauma Shock 2017;10:116-120


How to cite this URL:
Singh A, Ali S, Shetty R. Effectiveness and safety of polygeline in patients with hypovolemia due to trauma. J Emerg Trauma Shock [serial online] 2017 [cited 2021 Sep 27 ];10:116-120
Available from: https://www.onlinejets.org/article.asp?issn=0974-2700;year=2017;volume=10;issue=3;spage=116;epage=120;aulast=Singh;type=0