|Year : 2014 | Volume
| Issue : 4 | Page : 332-340
|Capnography during cardiopulmonary resuscitation: Current evidence and future directions
Bhavani Shankar Kodali, Richard D Urman
Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
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|Date of Submission||18-Oct-2013|
|Date of Acceptance||03-Mar-2014|
|Date of Web Publication||13-Oct-2014|
| Abstract|| |
Capnography continues to be an important tool in measuring expired carbon dioxide (CO 2 ). Most recent Advanced Cardiac Life Support (ACLS) guidelines now recommend using capnography to ascertain the effectiveness of chest compressions and duration of cardiopulmonary resuscitation (CPR). Based on an extensive review of available published literature, we selected all available peer-reviewed research investigations and case reports. Available evidence suggests that there is significant correlation between partial pressure of end-tidal CO 2 (PETCO 2 ) and cardiac output that can indicate the return of spontaneous circulation (ROSC). Additional evidence favoring the use of capnography during CPR includes definitive proof of correct placement of the endotracheal tube and possible prediction of patient survival following cardiac arrest, although the latter will require further investigations. There is emerging evidence that PETCO 2 values can guide the initiation of extracorporeal life support (ECLS) in refractory cardiac arrest (RCA). There is also increasing recognition of the value of capnography in intensive care settings in intubated patients. Future directions include determining the outcomes based on capnography waveforms PETCO 2 values and determining a reasonable duration of CPR. In the future, given increasing use of capnography during CPR large databases can be analyzed to predict outcomes.
Keywords: Capnography, cardiac arrest, cardiopulmonary resuscitation, end-tidal carbon dioxide
|How to cite this article:|
Kodali BS, Urman RD. Capnography during cardiopulmonary resuscitation: Current evidence and future directions. J Emerg Trauma Shock 2014;7:332-40
|How to cite this URL:|
Kodali BS, Urman RD. Capnography during cardiopulmonary resuscitation: Current evidence and future directions. J Emerg Trauma Shock [serial online] 2014 [cited 2022 Jun 30];7:332-40. Available from: https://www.onlinejets.org/text.asp?2014/7/4/332/142778
| Introduction|| |
Recent changes in Advanced Cardiac Life Support (ACLS) guidelines recommending the use of capnography during cardiopulmonary resuscitation (CPR) have led to many institutions revisiting their policies on CPR.  Currently, terminating resuscitative efforts in patients with cardiopulmonary arrest is an intuitive and personal call. Although capnography has now been incorporated into CPR to judge the effectiveness of chest compressions, increasing evidence suggests that it may offer an objective basis for determining patient prognosis or terminating CPR. The objective of this commentary is to review the underlying physiology of capnography during CPR, analyze evidence favoring capnography use during CPR, and outline future directions.
The carbon dioxide (CO 2 ) concentration can be plotted against time (time capnography) or against expired volume (volume capnography). In clinical practice, time capnography is the method that is commonly used. Infrared (IR) technology is the method of CO 2 analysis in practice. CO 2 is an asymmetric and polyatomic gas molecule that absorbs IR light at 4.3 mμ. The concentration of CO 2 in a gas sample can be measured by shining IR light on the respiratory gas sample and comparing the intensity of light that passes through the sample with the original light intensity.  The remaining IR light is detected by the IR detector and computed to display CO 2 waveform and CO 2 concentration. The CO 2 concentration can be also displayed as mmHg if atmospheric pressure is known.
Sidestream capnography is the most widely used method for continuous CO 2 monitoring [Figure 1].  It involves the use of disposable tubing (usually several feet long) and a T-piece adapter, which is inserted between the breathing circuit and endotracheal tube or other airway device. The tubing is connected from the side port on the adapter to a separate unit which contains the CO 2 sensor, and a sample of gas is aspirated through this disposable tubing during the respiratory cycle into the capnograph for measurement. Because this gas sample must travel through the tubing to the CO 2 sensor before it is processed, there is a slight delay in the display of the CO 2 waveform. One of the main advantages of sidestream capnography is that it can be used in nonintubated patients. For example, there are modified nasal cannulas which allow the sampling of expired gases even while administering supplemental oxygen. A drawback of sidestream capnography is that the tubing may become blocked from water vapor or secretions. The use of a filter between the tubing and the unit containing the CO 2 sensor minimizes this problem. Keeping the sample tubing antigravity can also minimize contamination from water vapor or secretions. A sidestream capnograph with a display of waveforms and end-tidal CO 2 (ETCO 2 ) values is shown in [Figure 2].
|Figure 1: Schematic representation of sidestream and mainstream capnography devices. Source: Puente EG, Antor MA, Bergese SD. Patient monitoring, equipment, and intravenous fluids. In: Urman RD, Kaye AD. Moderate and deep sedation in clinical practice, Cambridge University Press, 2012, with permission|
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|Figure 2: A sidestream capnograph with CO2 display showing waveforms (solid arrows) and end-tidal CO2 value (dashed arrow)|
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Mainstream capnography involves the use of an adapter between the breathing circuit and endotracheal tube [Figure 1]. In this method, a lightweight IR sensor is attached directly to the adapter. The sensor emits IR light to a photodetector on the other side of the adapter. During the respiratory cycle, respiratory gases flow through the adapter and the amount of CO 2 in the sample is measured immediately. There is no extra tubing, and there is no delay in the display of the waveform. The mainstream sensor is heated above body temperature, which prevents condensation and allows the sensor to function in high moisture environments. Condensation of moisture can interfere with the functioning of the unit. The earlier generations of mainstream capnometers had significant disadvantages, including bulky sensors requiring sterilization after each use and a risk of facial burns from the heated sensor. Newer versions, however, are more lightweight and have disposable adaptors. The temperature of the sensors is also decreased with better shielding to minimize facial burns. Further advances in mainstream capnography have produced smaller, light-weighted adapters for use in nonintubated patients. These units attach directly to the oxygen facemask or nasal cannula, allowing for CO 2 monitoring in a spontaneously breathing patient receiving sedation.
A typical time capnogram is divided into an inspiratory and expiratory segment [Figure 3]. The expiratory segment is further divided into three phases. Phase I represents dead space gases containing no CO 2 . Phase II is the mixture of dead space gases and alveolar gases. Phase III (alveolar plateau) represents alveolar gases. At the end of phase III, the CO 2 concentration decreases abruptly to zero representing the onset of next inhalation of CO 2 -free gases. The maximum value of CO 2 at the end of the breath is designated as end-tidal partial pressure of CO 2 (PETCO 2 ). It is generally lower than arterial partial pressure of CO 2 (PaCO 2 ) by about 5 mmHg in healthy subjects. The slope and the height of phase III is dependent on the CO 2 concentration of alveoli and their emptying patterns. In turn, the CO 2 concentration in the alveoli is dependent on the ventilation and perfusion characteristics of the alveoli. The caliber of respiratory conduits determines the ventilation to the alveoli; whereas, cardiac output alters perfusion of the alveoli. Therefore, it can be inferred that the height of phase III is predominantly dependent on the cardiac output, and the slope of phase II and III is dependent on the emptying patterns of the alveoli as well as ventilation-perfusion ratio [Figure 4].  The angle between phase II and III, which is referred to as the alpha angle (α) and is generally 100 degrees, is increased. The alpha angle (primarily representing variations in time constants within the lung) is thus an indirect indication of V/Q status of the lung [Figure 4]. , The angle between phase III and the descending limb is referred to as beta (β) angle, which is generally 90 degrees. The increase in this angle from 90 degrees suggests rebreathing of CO 2 . ,
|Figure 3: Time capnogram showing segments, phases, and angles. Inspiratory segment is phase 0, expiratory segment is divided into three phases: I, II, and III. Maximum value of carbon dioxide at the end of the expiration is designated as end-tidal partial pressure of carbon dioxide (PETCO2). The angle between phase II and III is α angle and between phase III and the inspiratory limb is β angle|
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|Figure 4: Capnogram (a) During normal breathing, α angle is 108 degrees. Capnogram (b) Recorded during bronchospasm. The angle is increased to 140 degrees|
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Physiology of capnography during CPR
During the administration of anesthesia, there is a good correlation between PETCO 2 values and cardiac index. , Several studies showed that this relationship between cardiac output and PETCO 2 values is also valid during CPR. ,,,, This principle formed the basis for the induction of capnography into current ACLS guidelines.  In a study by Jin et al., hemorrhagic shock was induced in five pigs by bleeding them followed by reinfusion of shed blood.  End-tidal CO 2 values were measured throughout this process. The authors determined that there was good correlation between cardiac output and PETCO 2 values during hemorrhage and reinfusion. Shibutani et al., replicated these results in patients undergoing aortic aneurysm surgery.  The authors demonstrated a significant correlation between the percent decreases of PETCO 2 versus the percent decreases in cardiac output in patients with constant ventilation.  Two mechanisms have been postulated to explain this relationship: firstly, decreased delivery of CO 2 to the lung and, secondly, increase in the alveolar dead space consequent to relatively high ventilation to perfusion rate, resulting in high ventilation/perfusion ratio. Both of these factors can result in the overall decrease in CO 2 output from the lungs during decreased cardiac output states. The correlation between PETCO 2 and cardiac output has two important implications during CPR. First, the effectiveness of CPR in producing adequate cardiac output can be monitored based on the PETCO 2 values. Secondly, abrupt increases in PETCO 2 values suggest concomitant increases in cardiac output and are indicative of the return of spontaneous circulation (ROSC) as shown in [Figure 5].
|Figure 5: Return of spontaneous circulation is indicated by an abrupt and sustained increase in the height of capnogram|
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Evidence favoring capnography use during CPR
We conducted an extensive literature search of peer-reviewed articles consisting of primary research studies, review papers, and case reports published between 1960 and 2014. We considered published research from all years. Keywords such as capnography, cardiopulmonary resuscitation, cardiopulmonary arrest survival, and end-tidal CO 2 were used for the initial search, and then we selected articles specifically related to the use of capnography during cardiopulmonary resuscitation and outcomes for our literature review.
Capnography is the most definitive evidence of correct endotracheal tube placement
In the past, it was believed that capnography would not be able to detect correct placement of an endotracheal tube due to decreased evolution of CO 2 from the lungs consequent to decreased cardiac output generated during CPR. This may be true with the use of colorimetric devices where the sensitivity of color change is not appreciable at low concentrations. Increasing use of waveform capnography for over 3 decades has helped to improve our understanding of its use in CPR. It is now well-appreciated that presence of small obtunded CO 2 waveforms during CPR reinforces tracheal location of an endotracheal tube. There is strong evidence of data demonstrating 100% sensitivity and 100% specificity in identifying correct endotracheal tube placements during CPR.  Studies of other devices such as colorimetric end-tidal CO 2 detectors, self-inflating esophageal detectors, and non-waveform end-tidal capnometers do not match up the accuracy of waveform capnography. ,, Based on the results of the Fourth National Audit Project of the Royal College of Anaesthetists and Difficult Airway Society, a strong recommendation was made to recognize the presence of abnormal (but not flat) capnogram trace during CPR.  Among cases reported in this study, where capnography might have altered the course of clinical events, there was an instance with 'flat capnogram' during prolonged CPR and this appeared to be a case of unrecognized esophageal intubation. Absence of CO 2 tracings during CPR should alert the physician in charge of CPR code team to reevaluate the location of endotracheal tube.  A recent study analyzed the data from Get With the Guidelines-Resuscitation (GWTG-R), which is a prospective observational registry of in-hospital cardiac arrest and resuscitation. In this study, patients whose endotracheal tube during CPR was confirmed by capnography were more likely to have ROSC.  Of the 176,054 patients entered into the GWTG-R database, 75,777 had an endotracheal tube placed. Confirmation of endotracheal tube position by capnography was documented in 43,034 (56%) cases. ROSC occurred in 39,063 (51.6%), and 13,474 (17.8%) survived to discharge. Patients whose endotracheal tube was confirmed by capnography or esophageal detector device were more likely to have ROSC (odds ratio 1.229, 1.179-1.282).  Occasionally, if the operator had provided mouth-to-patient ventilation (bystander mouth-to-mouth ventilation), the stomach contained CO 2 .  However, after seven waveforms, the expiratory gases should not contain CO 2 and consistency of CO 2 waveform height would not be maintained. 
Capnography as measure of cardiac output generated during CPR and ROSC
The height of the CO 2 waveform during CPR, which is a function of cardiac output during chest compression, should be monitored, and every effort should be made to achieve PETCO 2 values of at least 20 mmHg.  Usually during CPR, the cardiac index generated varies from 1.6 to 1.9 L/min/m 2 .  This generally corresponds to PETCO 2 values of over 20 mmHg.  Therefore, it seems reasonable to recommend attaining a PETCO 2 of 20 mmHg and above during CPR. Consistency of CPR is an important factor that may result in successful resuscitation, and continuous capnography helps to maintain consistent chest compression. Inadequate capnography waveforms can help the code team to explore factors impeding successful CPR. Such factors may include fatigue of the CPR performer, suboptimal chest compressions, ongoing hemorrhage, cardiac tamponade, and pneumothorax, among others. Capnography has been used to monitor effectiveness of various hand positions during chest compressions to determine the most optimum hand position facilitating effective compressions. Qvigstad et al.,  studied PETCO 2 values during CPR in cardiac arrest patients treated by the physician-manned ambulances. One minute of chest compressions at the internipple line (INL) was followed by four 30-s intervals with compressions at four different levels: 2 cm below the INL, 2 cm below and to the left of INL, and 2 cm below and to the right of INL. At the end of 30-s interval, median PETCO 2 was 23 mmHg at INL, 26 mmHg at 2 cm below INL, 26 mmHg and to the left of INL, and 28 mmHg at 2 cm below and to the right of INL. There were no significant differences in the PETCO 2 values between the various levels of hand positions. However, a noteworthy feature in this study was substantial interindividual variation among operators. It appears that capnography can help optimize hand positions to facilitate effective compressions during CPR.  Capnography has also been used to study the effectiveness of mechanical chest compression devices for CPR. Axelsson et al., studied the effectiveness of a mechanical active compression CPR device (ACD-CPR) in a group of patients 18 years of age and above who suffered out-of-hospital cardiac arrest.  Results were compared to a control group who underwent conventional CPR. The authors found higher PETCO 2 values in the ACD-CPR group than those in the conventional group. However, there is no evidence yet that mechanical device-assisted CPR contributes to better outcomes compared to conventional CPR. ,
Abrupt increase in PETCO 2 values during CPR suggests ROSC. Pokorna et al., observed sudden increase in PETCO 2 values at the moment of ROSC.  Based on the premise that a PETCO 2 level of 10 mmHg during CPR divides patients into those likely to be resuscitated (values > 10 mmHg) and those likely to die during CPR (values < 10 mmHg), the authors of this study tested the significance of a sudden increase in the PETCO 2 values in signaling the ROSC during CPR. One hundred and eight patients representing two extreme outcomes of CPR, were subdivided into two groups. The first group included 59 patients with ROSC followed by a stable spontaneous circulation, and the second group included 49 patients with no signs of ROSC. ROSC was associated with a sudden increase in PETCO 2 values that remained significantly higher than those before ROSC. PETCO 2 did not rise during the entire CPR in the second group of patients without ROSC and was lower than in the first group of patients. This study concluded that during unchanged ventilation in patients undergoing CPR, PETCO 2 values were significantly higher (about 10 mmHg) after ROSC than before ROSC. This implies that a sudden increase in PETCO 2 exceeding 10 mmHg may indicate ROSC. 
Prediction of survival based on capnography
In the last few years, considerable data has emerged supporting the view that capnography can predict and improve outcome following CPR. Pokorna et al. observed that patients undergoing CPR with PETCO 2 values greater than 10 mmHg during CPR were more likely to return to spontaneous circulation.  Grmec and Klemin  prospectively studied PETCO 2 trends during CPR in 139 adult victims of out-of-hospital nontraumatic cardiac arrests. The initial, final, average, minimal, and maximal PETCO 2 values were significantly higher in resuscitated patients than in nonresuscitated patients. Using initial, average, and final PETCO 2 values of 10 mmHg correctly identified 100% of the patients who were subsequently resuscitated (specificity 74.1, 90, and 81.4%, respectively). An important observation made by the authors of this study was that none of the patients with average, initial, and final PETCO 2 values of less than 10 mmHg was successfully resuscitated.  On the other hand, Callaham and Barton reported, based on the results of their study that patients who developed a pulse had a mean PETCO 2 of 19 ± standard deviation (SD) 14 mmHg at the start of resuscitation, and those who did not, had a mean PETCO 2 of 5 (±SD 4) mmHg (P < 0.0001).  An initial PETCO 2 value of at least 15 mmHg correctly predicted eventual return of pulse (sensitivity 71%, specificity 98%, positive predictive value of 91%, and a negative predictive value of 91%).  The observed variation in PETCO 2 values predicting successful outcome in the above studies is better explained by the observations made by Heradstveit et al. These authors also confirmed that patients who attained ROSC had significantly higher PETCO 2 values compared to those who did not have ROSC regardless of the initial cardiac rhythm or cause of the cardiac arrest.  However, an important additional finding of this study was that despite patients with ROSC having higher PETCO 2 values than those without ROSC, the actual PETCO 2 values were dependent on the cause of cardiac arrest. The respective PETCO 2 values with ROSC versus no ROSC, depending on the cause of cardiac arrest were as follows: cardiac 25.5 and 18 mmHg, pulmonary 33.7 and 17 mmHg, pulmonary embolus 16 and 6.7 mmHg, and unknown cause 20.5 and 9.7 mmHg.  Therefore, it is important to understand the limitation of using one absolute value of PETCO 2 to predict the prognosis as the cause of cardiac arrest can influence the PETCO 2 values, particularly if the cause is related to pulmonary function.
Einav et al. used mathematical modeling to predict survival from resuscitation based on computerized continuous capnography.  In this prospective cohort study of 30 patients who underwent CPR, the capnography data was collected during CPR and analyzed by a mathematician blinded to patient outcome. The primary outcome studied was to determine whether a meaningful relationship exists between the computerized PETCO 2 values and ROSC. Ten minutes after intubation, patients with ROSC had higher peak PETCO 2 values and a larger area under PETCO 2 curves when compared to patients without ROSC. Furthermore, cumulative max PETCO 2 > 20 mmHg at all-time points measured between 5 and 10 min postintubation best predicted ROSC (sensitivity = 88%, specificity = 77%). The authors of this study concluded that computerized PETCO 2 values could be a potentially valuable tool for early, real-time decision-making during resuscitation.
When to terminate cardiac resuscitation in a patient is difficult to answer at this stage. This may depend on the cause of cardiac arrest, age and prior morbidity, location where cardiac arrest occurs, and the personnel who are conducting the CPR.  Not surprisingly, resuscitation of cardiac arrests occurring in the operating room or post-anesthesia care unit shows better survival outcomes.  The following case report illustrates the complexity of decision making. This case, a 54-year-old man with no known cardiac disease who collapsed outdoors in a small rural community, may be an example of the longest known duration of CPR resulting in a favorable outcome.  This cardiac arrest was witnessed, and immediate cardiopulmonary resuscitation efforts were initiated by a bystander and a trained first responder nearby. After moving the patient inside a building and continuing resuscitation, first responders arrived with an automated external defibrillator, and ventricular fibrillation (VF) was documented. Defibrillation shocks were delivered, transiently restoring an organized electrocardiographic rhythm, but with no pulse at any time. The trachea was intubated, ventilation-controlled, and end-tidal CO 2 tension continuously monitored. Defibrillation continued and antiarrhythmic and inotropic drugs were administered intravenously. End-tidal CO 2 measurements confirmed good pulmonary blood flow with chest compressions, and resuscitation was continued until a stable cardiac rhythm was achieved after 96 min of pulselessness. During helicopter transport to the hospital, the patient was in cardiogenic shock but maintained a spontaneous circulation. Coronary angiography documented a left anterior descending coronary artery thrombotic occlusion that was treated successfully. Once in the hospital, the patient required circulatory and ventilatory support and hemodialysis for acute renal failure. He experienced a complete neurologic recovery to his pre-cardiac arrest state and was discharged from the hospital. An earlier case report described CPR administration for 107 min also resulting in patient survival. However, this patient, contrary to the first case, had a subnormal body temperature of 26.2°C after retrieval from cold water. 
In an effort to more accurately predict resuscitation outcomes, Salen et al. attempted to pair capnography with sonography at two community hospital emergency departments.  Over a 12-month period, 102 patients were enrolled, all undergoing cardiac sonography evaluations, ranging from one to five scans during cardiac resuscitation. The presence of sonographically identified cardiac activity at any point during the resuscitation was associated with survival to hospital admission of 27% in contrast to only 3% of those without cardiac activity. Higher median PETCO 2 levels (35 mmHg) were associated with improved chances of survival as compared to the median PETCO 2 levels for nonsurvivors (13.7 mmHg). Both the sonographic detection of cardiac activity and PETCO 2 levels higher than 16 mmHg were significantly associated with survival from resuscitation in the emergency department. However, logistic regression analysis demonstrated that prediction of survival using capnography was not enhanced by the addition of cardiac sonography.
While the use of capnography data during CPR shows promise in predicting survival of patients following cardiac arrest, more robust data is required to formulate more assertive recommendations in the future.
Role of capnography in therapeutic hypothermia and extracorporeal life support (ECLS)
Cooling strategies to improve patient outcomes following ROSC have been described in recent literature, showing tangible benefit in terms of neurologic outcome in patients who suffered out-of-hospital cardiac arrest.  Although evidence points to benefit from an early initiation of therapeutic cooling in post-cardiac arrest patients who were initially found to be in VF, it is still unclear when, how, and for what duration of time it should be applied.  Investigation is needed to help determine the role of PETCO 2 during CPR to guide initiation, method, and duration of this emerging neuroprotective strategy. Likewise, there is encouraging evidence for the use of ECLS strategies in refractory cardiac arrest (RCA). ,, A 2009 French guideline addressing indications for ECLS suggests using a PETCO 2 value of ≥10 mmHg to guide the initiation of ECLS following out-of-hospital cardiac arrest.  The most recent study by Le Guen et al., that evaluated patients who experienced a witnessed out-of-hospital RCA confirmed the validity of PETCO 2 level ≥10 mmHg for the initiation of ECLS, although this value was thought to be possibly too liberal given lower values in patients who survived less than 24 h. 
Capnography in the intensive care setting
Currently, capnography is not the standard of care in some intensive care units. The value of capnography is underrecognized in this area unlike in the operating rooms.  There are many advantages of capnography in a ventilated patient and these include its value in CPR. According to the US National Registry of Cardiopulmonary Resuscitation, 46% of cardiac arrests (40,050 out of 86,748) occur in intensive care units.  Many of these cardiac arrests have worst outcome (15.5 survived to discharge) compared to other settings. Therefore, it is logical that all intensive care units should consider using capnography to monitor ventilation, cardiac output, and will serve as a valuable tool in the event of cardiac arrest. This recognition of capnography by the intensivists is on the rise, and a demand for ventilators with capnography capability has arisen nationally.
Capnography and ACLS guidelines
Anesthesiologists have incorporated capnography into clinical practice approximately 25 years ago. The reason for this change of practice was in large part attributed to American Society of Anesthesiologists (ASA) closed claim analysis which revealed that 93% of anesthesia mishaps could have been prevented if capnography was used together with pulse oximetry. ,,, Similarly, the recent National Airway Project of Royal College of Anaesthetists and Difficult Airway Society revealed that capnography could have prevented 74% of airway-related deaths in the intensive care units. , Furthermore, capnography is the most reliable method of determining the correct position of the endotracheal tube during CPR when the pulmonary circulation is considerably low. The National Airway Project emphasized that if no CO 2 waveform is obtained during CPR, the endotracheal tube is most likely not in the trachea. The pulmonary circulation produced by the chest compressions is enough to produce visible CO 2 waveforms, thus confirming the position of the endotracheal tube. This is probably one of the main reasons why American Heart Association (AHA) strongly recommended the use of capnography during CPR. The AHA also recognized the value of capnography waveform height/CO 2 values as an indirect measure of pulmonary circulation generated by the chest compressions. Another reason for inclusion of capnography during CPR is the abrupt rise in CO 2 suggesting ROSC. International Liaison Committee on Resuscitation conferences are periodically held to evaluate resuscitation science and generate conclusions and recommendations which are published as consensus science statements and treatment recommendations. This review of science and guidance documents has been occurring on a 5-year cycle. The most recent guidelines from the AHA and European Resuscitation Council (ERC) resulted from the 2010 International Consensus Conference in February 2010, attended by 313 experts from 30 countries.  Part 8.1 of the guidelines states that "Continuous waveform capnography is recommended in addition to clinical assessment as the most reliable method of confirming and monitoring correct placement of an endotracheal tube". This statement is based on Class 1 level of evidence (LOE A), meaning that it is based on the data derived from multiple randomized clinical trials or meta-analyses. In addition, the guideline states that "providers should observe a persistent capnographic waveform with ventilation to confirm and monitor endotracheal tube placement in the field, in the transport vehicle, or arrival at the hospital and after any patient transfer to reduce the risk of unrecognized tube misplacement or displacement".  The introduction of these recommendations and guidelines will generate substantial data in the future to accurately predict the course and outcome of CPR. As mentioned previously, the value of capnography during CPR has been highlighted in case reports and public media. As previously discussed, a recent case report highlighted the value of capnography during CPR in a patient who sustained cardiac arrest and collapsed in a grocery store.  Capnography assured that effective CPR was being performed and the resuscitation team continued with resuscitation efforts for 96 min when sustained spontaneous heart beat and circulation were finally restored. Throughout the resuscitation, end-tidal CO 2 was consistently in the 28-36 mmHg range during VF/CPR. These levels of CO 2 were consistent with effective chest compression generating reasonable pulmonary blood flow, justifying continuation of resuscitation. When the 12 th shock restored VF to an organized rhythm, there was no palpable pulse, but a PETCO 2 of 37 mmHg suggested that spontaneous circulation had resumed, and CPR was terminated. The patient underwent coronary stent placement and was discharged on the 10 th day with no neurologic or cognitive deficit.
Based on the current guidelines of AHA/ACLS, our institution has mounted a capnography unit on a movable code stand [Figure 6]. The unit is turned on at the first notification of the code so that it undergoes the calibration process by the time the code team arrives at the code location. In addition, the stand has a video laryngoscope for an unanticipated difficult intubation.
Limitations of capnography in CPR
Lack of availability of equipment is a limitation in the majority of situations. However, it is likely that, in due course, institutional guidelines will require capnography to be used during every CPR regardless of the location. The National Airway Project strongly recommends this approach and asks clinicians to use capnography during CPR. If the equipment is not available, the cause of unavailability must be stated. , It is conceivable that, in due course, capnography equipment use will become standard during CPR. Although older capnographs were bulky and marketed as stand-alone units, many portable capnograph unit types are now available. These can be mounted on a mobile stand as described above or can be carried. Many capnographs require a calibration period for several minutes before functionality could be achieved. Consequently, the monitor can be switched on as soon as a call for CPR is received. This time frame should be adequate enough for calibration, and the device should be ready to show CO 2 waveforms. Use of a capnometer that only displays CO 2 values but not waveforms is not acceptable during CPR. It is important to observe small but consistent CO 2 waveforms during CPR not only to confirm the endotracheal tube placement but also to monitor the efficacy of CPR. The functionality of the capnograph unit can be easily tested by the operator blowing into the capnograph sampling tube after calibration. A good waveform and end-tidal CO 2 value of about 35 mmHg demonstrates functionality of the unit. Blockage of the sampling tube by the secretions from the patient can occur, but this should not be a major predicament. If this happens, the sampling tube can be easily changed. Personnel using capnograph units will require training and interpretation of CO 2 waveforms. In our institution, we have developed an online course for all physicians who are likely to be called for CPR. In the intensive care units, the capnographs should be used continuously so that personnel become familiar with its use so that they are more adept at interpreting capnography during a crisis.
| Conclusion and Future Directions|| |
The AHA and Association of Anaesthetists of Great Britain and Ireland have rightfully endorsed the use of capnography during CPR. Other regional associations in many countries are inducting capnography into CPR guidelines. In our institution, the physicians are required to undergo an online training module that explains the physiology, functionality, and guidelines aimed towards successful resuscitation. The respiratory therapist is responsible for bringing the capnography units to all codes. Several intensive care units are upgrading their ventilators to enable the use of capnography.
Presence of consistent blunted waveforms reinforces tracheal placement of the endotracheal tube. Furthermore, the effectiveness of CPR can be monitored by consistently producing PETCO 2 values greater than 10-20 mmHg. Although there are 10 mmHg variations in PETCO 2 values from various studies that predict positive outcome, the aim should be to maintain consistently higher PETCO 2 values to generate optimum cardiac output. This may necessitate a change in chest compressions or change in the operator performing CPR. An abrupt increase in PETCO 2 values suggests ROSC.
The future focus of capnography in CPR will be in determining the outcomes based on capnography waveform PETCO 2 values. With the increasing use of capnography during CPR, an opportunity to analyze large databases to predict outcomes of CPR would be possible. Another important focus point will be the determination of reasonable duration of CPR before a decision to terminate it is made. Currently, this responsibility rests with the CPR code leader. With more evidence emerging, the anecdotal positive outcomes following capnography use during CPR reported in a few well-known cases will transform into more definitive recommendations in the future. In the meantime, manufacturers of capnography devices will direct their efforts in producing cost-effective, portable devices that are essential for use in CPR given the nature of occurrence at unexpected locations.
| Acknowledgment|| |
We would like to acknowledge Mr. James Bell for creating figure graphics.
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Dr. Richard D Urman
Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts
Source of Support: None, Conflict of Interest: None
[Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5], [Figure 6]
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