Journal of Emergencies, Trauma, and Shock
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Year : 2015  |  Volume : 8  |  Issue : 3  |  Page : 159-166

Pyruvate dose response studies targeting the vital signs following hemorrhagic shock

Department of Anesthesiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA

Correspondence Address:
Pushpa Sharma
Department of Anesthesiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland
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Source of Support: USAMRMC award no. W81XWH-10-1-0507 to PS., Conflict of Interest: None

DOI: 10.4103/0974-2700.160729

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Objectives: To determine the optimal effective dose of sodium pyruvate in maintaining the vital signs following hemorrhagic shock (HS) in rats. Materials and Methods: Anesthetized, male Sprague-Dawley rats underwent computer-controlled HS for 30 minute followed by fluid resuscitation with either hypertonic saline, or sodium pyruvate solutions of 0.5 M, 1.0 M, 2.0 M, and 4.0 M at a rate of 5ml/kg/h (60 minute) and subsequent blood infusion (60 minute). The results were compared with sham and non- resuscitated groups. The animals were continuously monitored for mean arterial pressure, systolic and diastolic pressure, heart rate, pulse pressure, temperature, shock index and Kerdo index (KI). Results: The Sham group remained stable throughout the experiment. Non-resuscitated HS animals did not survive for the entire experiment due to non-viable vital signs and poor shock and KI. All fluids were effective in normalizing the vital signs when shed blood was used adjunctively. Sodium pyruvate 2.0 M was most effective, and 4.0 M solution was least effective in improving the vital signs after HS. Conclusions: Future studies should be directed to use 2.0 M sodium pyruvate adjuvant for resuscitation on multiorgan failure and survival rate in HS.

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