Journal of Emergencies, Trauma, and Shock
Home About us Editors Ahead of Print Current Issue Archives Search Instructions Subscribe Advertise Login 
Users online:205   Print this pageEmail this pageSmall font sizeDefault font sizeIncrease font size   


 
 Table of Contents    
CASE REPORT  
Year : 2011  |  Volume : 4  |  Issue : 2  |  Page : 306-308
Multimodal imaging tools for diagnosis of fat embolism


1 Department of Clinical Neurosciences, Calgary Stroke Program, Calgary, Canada
2 Department of Clinical Neurosciences, Calgary Stroke Program, Calgary, Canada; Department of Neurology, All India Institute of Medical Sciences, New Delhi, India
3 Department of Clinical Neurosciences, Calgary Stroke Program, Calgary, Canada; Hotchkiss Brain Institute, Calgary, Canada; Department of Radiology, University of Calgary, Calgary, Canada

Click here for correspondence address and email

Date of Submission15-Apr-2010
Date of Acceptance23-Sep-2010
Date of Web Publication18-Jun-2011
 

   Abstract 

It is important to consider several differential diagnoses in a patient presenting with altered sensorium following surgery. Fat embolism syndrome (FES) is a serious condition that needs to be excluded. Although criteria for diagnosis of FES are available, all patients may not satisfy them. We discuss a patient who presented with an incomplete triad of the FES, where the diagnosis was supported by transcranial doppler monitoring of microembolic signals and magnetic resonance imaging.

Keywords: Fat embolism, microembolic signals, MRI, transcranial Doppler

How to cite this article:
Shobha N, Bermejo PG, Bhatia R, Choi Y, Smith EE, Demchuk AM. Multimodal imaging tools for diagnosis of fat embolism. J Emerg Trauma Shock 2011;4:306-8

How to cite this URL:
Shobha N, Bermejo PG, Bhatia R, Choi Y, Smith EE, Demchuk AM. Multimodal imaging tools for diagnosis of fat embolism. J Emerg Trauma Shock [serial online] 2011 [cited 2019 Jul 21];4:306-8. Available from: http://www.onlinejets.org/text.asp?2011/4/2/306/82232



   Introduction Top


Altered sensorium in the postoperative period poses diagnostic and therapeutic challenges to the treating physician. Fat embolism syndrome (FES) is an important possibility, especially in the setting of orthopedic surgeries. FES is a serious manifestation of fat embolism that involves petechial rash, deteriorating mental status, and progressive respiratory insufficiency. In the perioperative period, an incidence of fat embolism between 3.5% and 5% is noted with the strategy of early fixation of fractures. [1] We discuss the utility of transcranial doppler and MR imaging in the diagnosis of FES in our patient.


   Case Report Top


Mrs. R, an 84 year-old-lady, with no significant past medical history, presented to the emergency department with a fracture of the left femoral neck following a fall. Hemiarthroplasty was performed the following day. Post-procedure, the patient failed to regain her sensorium for more than 10 h. Examination revealed a febrile patient with a pulse rate of 112/min and a blood pressure of 110/80. General physical exam and cardiovascular exams were normal; she was intermittently tachypneic with a respiratory rate of 40/min and clear lungs. She was stuporous with minimal wincing to pain, but no verbal or motor response, deep tendon reflexes were sluggish and plantars were extensor. Fundoscopic examination was normal. The laboratory parameters are shown in [Table 1]. The renal, liver function tests, and the electrolytes were unremarkable. Arterial blood gas analysis did not show hypoxemia, paO 2 was 102 mm Hg; and pulse oximetry showed an O 2 saturation of 99%. In view of deteriorating sensorium, she was intubated and ventilated. CT scan of the brain was unremarkable. CT scan of her chest did not show evidence of pulmonary embolism, venous doppler of the lower limbs was normal. A transthoracic ECHO did not reveal a patent foramen ovale, elevated pulmonary artery pressures, or any other abnormality. Blood cultures showed no growth.
Table 1: Laboratory parameters


Click here to view


MRI brain done 2 days later showed a shower of emboli with multiple scattered tiny hyperintense DWI (diffusion-weighted imaging) [Figure 1]a lesions in bilateral cortical areas, deep watershed regions, basal ganglia, and the posterior fossa. Some of these lesions were hypointense on apparent diffusion coefficient (ADC) [Figure 1]b map and a few of them were isointense. Gradient Echo (GRE) showed hypointense lesions suggestive of petechial hemorrhages [Figure 1]c. There was no vascular occlusion or stenosis on MR angiography.
Figure 1: MRI brain showed restricted diffusion on diffusion-weighted (DWI) sequences (a) in bilateral cortical areas, deep watershed regions, and basal ganglia, hypointense on apparent diffusion coefficient (ADC) (b) and gradient-recalled echo (GRE) (c)

Click here to view


Transcranial Doppler performed for a duration of 30 min detected emboli in bilateral middle cerebral arteries (MCAs). PMD (Spencer Technologies, Inc; PMD 100 mol/L) was used along with a 2-MHz pulsed-wave transducer to generate simultaneous M-mode and spectral TCD displays. Probe fixation using a head frame (Marc 500, Spencer Technologies) was used for monitoring. The insonation depth for spectrogram recording was between 45 and 65 mm for the ipsilateral MCA.

Microembolic signals (MES) were defined as high-amplitude, unidirectional, transient signals lasting less than 300 ms [Figure 2] and associated with an acoustic resemblance to a characteristic chirp or snap. Ten MESs each were detected in either MCAs. The intensity of solid MESs ranged from 7 to 9 dB, and the duration ranged from 40 to 60 ms. These emboli had an Relative Energy Index of MES (REIM) of 0.40. The relative energy index of MES (REIM) was obtained by multiplication of maximum duration of MES in a 3-mm gate (MaxD) with MES maximum intensity adjusted for the intensity of background blood flow (MaxI) on Power M-mode display. [2] A final diagnosis of FES was made. She received conservative management in the form of antiplatelet agents, intravenous fluids, deep vein thrombosis prophylaxis, and ventilatory support. Unfortunately, she progressively deteriorated and died after 5 days.
Figure 2: Transcranial Doppler of the middle cerebral artery showing microembolic signals

Click here to view



   Discussion Top


The incidence of symptomatic fat embolism in a single long bone fracture ranges between 0.5 and 3%. [3] There are two mechanisms cited for the genesis of fat embolism. [4] The first mechanism suggests that the dislodged marrow fat enters the systemic circulation during long bone fractures due to increased intramedullary pressure as seen in closed fractures or surgical manipulation even in the absence of cardiac or pulmonary shunts, bypassing the filtration mechanisms of the pulmonary capillary bed. The second proposed mechanism is that, during periods of stress, secreted catecholamines trigger metabolism of the body fat stores leading to fat embolism. MES to brain with TCD monitoring have been recorded more commonly during impaction of a cemented component or after relocation of the hip than during impaction of the acetabulum component. [5] The FES may manifest after a latent period of 12-48 h. [1] The major diagnostic criteria of FES are hypoxia, deteriorating mental status, and petechiae; minor signs include tachycardia >120 beats/min, fever usually <39΀ C, sudden drop in hemoglobin of >20% of the admission value, sudden drop in platelet counts of >50% of the admission value, retinal changes, jaundice, oliguria, high erythrocyte sedimentation rate (ESR >71mm/h), and fat macroglobulinemia. [6],[7] Our patient did not meet the criteria for FES by Gurd [6],[7] or Schonfeld. [8] However, modern imaging tools such as MR brain and transcranial doppler were not available when these criteria were formulated.

CT brain in most cases is normal. The diagnostic features of cerebral fat embolism on MRI are multiple small, nonconfluent hyperintense lesions on DWI and T2-weighted images, usually situated in the cerebral white matter and deep gray matter. [9] DWI lesions represent the cytotoxic edema which develops initially, areas of increased signal intensity on T2-weighted scans presumably reflect vasogenic edema, which develops at a later stage. [10] However, some DWI lesions are isointense on ADC suggesting a component of vasogenic edema too. [9] Our patient had MR findings suggestive of fat embolism.

TCD monitoring for cerebral emboli was performed in vivo in long bone fractures in patients with FESs. [11]

MES are high-amplitude, unidirectional, transient signals lasting <300 ms with acoustic resemblance characteristic "snaps, tonal chirps, or moans". [12] Acoustic artifacts can be differentiated from MES by their bidirectional nature and a low frequency (<400 Hz).It is difficult to differentiate different types of solid emboli by TCD like atherosclerotic, fat, or platelet emboli. Gaseous MES are often differentiated by their bidirectionality and higher intensities (>25 dB above background). [12] However, in the appropriate clinical scenario like ours, in the absence of other sources of embolism such as cardiac or carotid disease or venous thrombosis, the likelihood of the emboli being fat emboli is quite high.

Early institution of oxygen therapy reduces the effect of hypoxemia and the systemic complications of FES. [13] Medications including steroids, heparin, alcohol, and dextran have been tried but with uncertain benefit. [7]

The mortality in patients with FES and long bone fractures ranges from 0.9% to 8.7%, but with improvement in supportive therapy, and early stabilization and definitive fixation of fractures, the overall outcomes have improved recently. [1]


   Conclusion Top


Diagnosis of FES requires a high index of suspicion. Diagnosis may not be possible with clinical criteria in all cases. MR imaging of the brain and transcranial doppler monitoring of microembolism to the brain are useful techniques in supporting the diagnosis of FES. Transcranial doppler is a useful modality in diagnosing cerebral microembolism especially in situations where MR brain is not feasible due to technical or logistic reasons.

 
   References Top

1.Akhtar S. Fat embolism. Anesthesiol Clin. 2009; 27:533-50.   Back to cited text no. 1
    
2.Choi Y, Saqqur M, Stewart E, Stephenson C, Roy J, Boulanger JM, et al. Relative energy index of microembolic signal can predict malignant microemboli. Stroke. 2010; 41:700-6.  Back to cited text no. 2
    
3.ten Duis HJ. The fat embolism syndrome. Injury. 1997; 28: 77-85.  Back to cited text no. 3
    
4.de Feiter PW, van Hooft MA, Beets-Tan RG, Brink PR. Fat embolism syndrome: Yes or no? J Trauma 2007; 63:429-31.  Back to cited text no. 4
[PUBMED]    
5.Edmonds CR, Barbut D, Hager D, Sharrock NE. Intraoperative cerebral arterial embolization during total hip arthroplasty. Anesthesiology 2000; 93:315-8.  Back to cited text no. 5
[PUBMED]  [FULLTEXT]  
6.Gurd AR. Fat embolism: an aid to diagnosis. J Bone Joint Surg Br. 1970; 52:732-73-7.  Back to cited text no. 6
[PUBMED]  [FULLTEXT]  
7.Taviloglu K, Yanar H. Fat embolism syndrome. Surg Today 2007; 37:5-8.  Back to cited text no. 7
[PUBMED]  [FULLTEXT]  
8.Schonfeld SA, Ploysongsang Y, DiLisio R, Crissman JD, Miller E, Hammerschmidt DE, et al. Fat embolism prophylaxis with corticosteroids: A prospective study in high-risk patients. Ann Intern Med 1983; 99:438-43.  Back to cited text no. 8
[PUBMED]    
9.Butteriss DJ, Mahad D, Soh C, Walls T, Weir D, Birchall D. Reversible cytotoxic cerebral edema in cerebral fat embolism. AJNR Am J Neuroradiol 2006; 27:620-3.  Back to cited text no. 9
[PUBMED]  [FULLTEXT]  
10.Parizel PM, Demey HE, Veeckmans G, Verstreken F, Cras P, Jorens PG, et al. Early diagnosis of cerebral fat embolism syndrome by diffusion-weighted MRI (starfield pattern). Stroke 2001; 32:2942-4.   Back to cited text no. 10
[PUBMED]  [FULLTEXT]  
11.Forteza AM, Koch S, Romano JG, Zych G, Bustillo IC, Duncan RC, et al. Transcranial Doppler detection of fat emboli.Stroke 1999; 30:2687-91.  Back to cited text no. 11
[PUBMED]  [FULLTEXT]  
12.Edmonds HL Jr, Isley MR, Sloan TB, Alexandrov AV, Razumovsky AY. American Society of Neurophysiologic Monitoring and American Society of Neuroimaging Joint Guidelines for transcranial Doppler ultrasonic monitoring. J Neuroimaging 2010 Mar 17. [Epub ahead of print]  Back to cited text no. 12
    
13.Wong MV, Tsui HF, Young SH, Chan KM, Cheng JC. Continuous pulse oximeter, for in apparent hypoxemia after long bone fractures. J Trauma 2004;56:356-62.  Back to cited text no. 13
    

Top
Correspondence Address:
Andrew M Demchuk
Department of Clinical Neurosciences, Calgary Stroke Program, Calgary, Canada; Hotchkiss Brain Institute, Calgary, Canada; Department of Radiology, University of Calgary, Calgary, Canada

Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-2700.82232

Rights and Permissions


    Figures

  [Figure 1], [Figure 2]
 
 
    Tables

  [Table 1]

This article has been cited by
1 Case report - Cerebral fat metabolism syndrome after bilateral femoral fracture [Kasuistik - Zerebrales Fettemboliesyndrom nach Beidseitiger Oberschenkelfraktur]
Wöhler, P. and Hirl, B. and Kellermann, W.
Anasthesiologie Intensivmedizin Notfallmedizin Schmerztherapie. 2013; 48(5): 300-302
[Pubmed]
2 Alveolar hemorrhage in a case of fat embolism syndrome: A case report with short systemic review
Dash, S.K. and Bansal, A. and Wankhade, B.S. and Sharma, R.
Lung India. 2013; 30(2): 151-154
[Pubmed]



 

Top
  
 
  Search
 
  
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Email Alert *
    Add to My List *
* Registration required (free)  


    Abstract
    Introduction
    Case Report
    Discussion
    Conclusion
    References
    Article Figures
    Article Tables

 Article Access Statistics
    Viewed2622    
    Printed141    
    Emailed0    
    PDF Downloaded15    
    Comments [Add]    
    Cited by others 2    

Recommend this journal