Journal of Emergencies, Trauma, and Shock
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BASIC SCIENCE RESEARCH
Year : 2009  |  Volume : 2  |  Issue : 1  |  Page : 6-9

Vascular endothelial growth factor and acute mountain sickness


1 Department of Emergency Medicine, University of Iowa, Iowa City IA 52242-1009, USA
2 Department of Surgery, Section of Emergency Medicine, Yale University School of Medicine, 64 Congress Avenue, Suite 260, New Haven, CT 06519-1315, USA

Correspondence Address:
Eric Nilles
Department of Emergency Medicine, University of Iowa, Iowa City IA 52242-1009
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-2700.44675

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Study Objective: Despite causing significant morbidity throughout the mountainous regions of the world, the pathophysiology of acute mountain sickness (AMS) remains poorly understood. This study aims to improve the understanding of altitude illness by determining if vascular endothelial growth factor (VEGF) plays a role in the development of AMS. The purpose of this study was to determine if elevated plasma VEGF correlates with increased symptoms of AMS at high altitude. Patients and Methods: This is a prospective study of a cohort of healthy climbers on Denali (Mount McKinley) in Alaska at 14, 200 feet. Baseline demographics, medications, rates of ascent, and AMS scores were recorded. Pulse oximetry measurements and venous blood samples were obtained. Comparisons were made between mountaineers with and without AMS. Results: Seventy-two climbers were approached for participation in the study; 21 (29%) refused. Of the 51 climbers participating in the study, 14 subjects (27.5%) had symptoms of AMS and 37 subjects (72.5%) were free of symptoms of AMS. Plasma VEGF levels were 79.14 pg/dl (SD: 121.44) and 57.57pg/dl (SD: 102.71) in the AMS and non-AMS groups, respectively. These results were nonsignificant. Similarly, comparison of sex, age, rate of ascent, pulse oximetry values, or history of altitude illness did not reveal significant differences between the AMS and non-AMS groups. Conclusion: This study does not provide evidence in support of the theory that plasma VEGF correlates with symptoms of AMS.


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